Derby County welcome Fulham to Pride Park in the Sky Bet Championship.
Chelsea and Tottenham go head-to-head in the Premier League as they meet at Stamford Bridge.
Thomas Frank's promotion-chasing Brentford welcome Blackburn to Griffin Park in the Sky Bet Championship. Bradley Dack struck early on to help Rovers to a 1-0 win in the reverse game.
Sutton United host Barrow in the Vanarama National League at Borough Sports Ground.
Brendan Rodgers's Leicester City welcome Premier League champions Manchester City to the King Power Stadium. Pep Guardiola's side ran out 3-1 winners when the sides met earlier this season.
Mikel Arteta's Arsenal welcome another of his former clubs - Everton - to the Emirates Stadium in the Premier League. A tightly fought reverse fixture at Goodison ended 0-0.
Cardiff City welcome Nottingham Forest to the Cardiff City Stadium in the Sky Bet Championship. Nathaniel Mendez-Laing scored to secure the Bluebirds the three points in the reverse game.
Chelsea and Bayern Munich meet in the Champions League Round of 16 first leg at Stamford Bridge.
Millwall take on Birmingham City at The Den in the Sky Bet Championship. The sides shared the spoils in a 1-1 draw when they met earlier on in the season.
Manchester City travel to the Santiago Bernabeu to take on Real Madrid in the first leg of their UEFA Champions League Round of 16 match.
Lyon and Juventus meet in the UEFA Champions League at Parc Olympique Lyonnais as they play their Round of 16 first leg tie.